Synergistic Antitumor Effect between Gefitinib and Fractionated Irradiation in Anaplastic Oligodendrogliomas Cannot Be Predicted by the Egfr Signaling Activity

Sophie Pinel; Jihane Mriouah; Marc Vandamme; Alicia Chateau; François Plénat; Eric Guérin; Luc Taillandier; Valérie Bernier-Chastagner; Jean-Louis Merlin; Pascal Chastagner

doi:10.1371/journal.pone.0068333

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Open Access

Peer-reviewed

Research Article

Synergistic Antitumor Effect between Gefitinib and Fractionated Irradiation in Anaplastic Oligodendrogliomas Cannot Be Predicted by the Egfr Signaling Activity

Sophie Pinel ,

* E-mail: sophie.pinel@univ-lorraine.fr

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France
⨯
Jihane Mriouah,

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France
⨯
Marc Vandamme,

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France
⨯
Alicia Chateau,

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France
⨯
François Plénat,

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France, Service d’Anatomie et Cytologie Pathologique, Hôpital de Brabois CHRU Nancy, Vandoeuvre-les-Nancy, France
⨯
Eric Guérin,

Affiliation EA 4438, Université de Strasbourg, Strasbourg, France
⨯
Luc Taillandier,

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France, Service de Neurologie, Hôpital Central CHRU de Nancy, Nancy, France
⨯
Valérie Bernier-Chastagner,

Affiliation Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy, France
⨯
Jean-Louis Merlin,

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France, Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy, France
⨯
Pascal Chastagner

Affiliations Université de Lorraine, CRAN, UMR 7039, Campus Science, Vandoeuvre-les-Nancy, France, CNRS, CRAN, UMR 7039, Vandoeuvre-les-Nancy, France, Service d’Onco-Hématologie Pédiatrique, Hôpital d’Enfants CHRU de Nancy, Vandoeuvre-les-Nancy, France
⨯

Synergistic Antitumor Effect between Gefitinib and Fractionated Irradiation in Anaplastic Oligodendrogliomas Cannot Be Predicted by the Egfr Signaling Activity

Sophie Pinel,
Jihane Mriouah,
Marc Vandamme,
Alicia Chateau,
François Plénat,
Eric Guérin,
Luc Taillandier,
Valérie Bernier-Chastagner,
Jean-Louis Merlin,
Pascal Chastagner

Published: July 18, 2013
https://doi.org/10.1371/journal.pone.0068333

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