A Synthetic Model of Human Beta-Thalassemia Erythropoiesis Using CD34+ Cells from Healthy Adult Donors

Y. Terry Lee; Ki Soon Kim; Colleen Byrnes; Jaira F. de Vasconcellos; Seung-Jae Noh; Antoinette Rabel; Emily R. Meier; Jeffery L. Miller

doi:10.1371/journal.pone.0068307

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Research Article

A Synthetic Model of Human Beta-Thalassemia Erythropoiesis Using CD34+ Cells from Healthy Adult Donors

Y. Terry Lee ,

Contributed equally to this work with: Y. Terry Lee, Ki Soon Kim

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ki Soon Kim ,

Contributed equally to this work with: Y. Terry Lee, Ki Soon Kim

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Colleen Byrnes,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jaira F. de Vasconcellos,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Seung-Jae Noh,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Antoinette Rabel,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Emily R. Meier,

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jeffery L. Miller

* E-mail: jm7f@nih.gov

Affiliation Molecular Genomics and Therapeutics Section, Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

A Synthetic Model of Human Beta-Thalassemia Erythropoiesis Using CD34+ Cells from Healthy Adult Donors

Y. Terry Lee,
Ki Soon Kim,
Colleen Byrnes,
Jaira F. de Vasconcellos,
Seung-Jae Noh,
Antoinette Rabel,
Emily R. Meier,
Jeffery L. Miller

Published: July 8, 2013
https://doi.org/10.1371/journal.pone.0068307

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Erythroblasts
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Beta-thalassemia
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Cell differentiation
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Erythropoiesis
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