Mesothelin Virus-Like Particle Immunization Controls Pancreatic Cancer Growth through CD8+ T Cell Induction and Reduction in the Frequency of CD4+foxp3+ICOS− Regulatory T Cells

Open Access

Peer-reviewed

Research Article

Mesothelin Virus-Like Particle Immunization Controls Pancreatic Cancer Growth through CD8⁺ T Cell Induction and Reduction in the Frequency of CD4⁺foxp3⁺ICOS⁻ Regulatory T Cells

Sheng Zhang,

Affiliation Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
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Lin-Kin Yong,

Affiliation Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
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Dali Li,

Affiliation Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
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Rafael Cubas,

Affiliation Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
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Changyi Chen,

Affiliation Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
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Qizhi Yao

* E-mail: qizhiyao@bcm.edu

Affiliations Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
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Regulatory T cells
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T cells
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Pancreatic cancer
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Cytotoxic T cells
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Malignant tumors
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Cell staining
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Cancers and neoplasms
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Mouse models
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