Increased CD4+ T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?

Michiel van der Flier; Dyana B. Sharma; Silvia Estevão; Marieke Emonts; Denise Rook; Jan A. Hazelzet; Johannes B. van Goudoever; Nico G. Hartwig

doi:10.1371/journal.pone.0068294

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Peer-reviewed

Research Article

Increased CD4⁺ T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?

Michiel van der Flier ,

* E-mail: m.flier@cukz.umcn.nl

Current address: Department of Pediatrics and Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Affiliations Department of Pediatric Infectious Diseases and Immunology, Erasmus MC - Sophia, Rotterdam, The Netherlands, Laboratory of Pediatrics, Pediatric Infectious Diseases Group, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯
Dyana B. Sharma,

Affiliations Department of Pediatric Infectious Diseases and Immunology, Erasmus MC - Sophia, Rotterdam, The Netherlands, Laboratory of Pediatrics, Pediatric Infectious Diseases Group, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯
Silvia Estevão,

Affiliation Laboratory of Pediatrics, Pediatric Infectious Diseases Group, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯
Marieke Emonts,

Affiliation Department of Pediatric Infectious Diseases and Immunology, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯
Denise Rook,

Affiliation Neonatal Intensive Care Unit, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯
Jan A. Hazelzet,

Affiliation Pediatric Intensive Care Unit, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯
Johannes B. van Goudoever,

Current address: Department of Pediatrics, Academic Medical Centre, Amsterdam, The Netherlands

Affiliation Neonatal Intensive Care Unit, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯
Nico G. Hartwig

Affiliations Department of Pediatric Infectious Diseases and Immunology, Erasmus MC - Sophia, Rotterdam, The Netherlands, Laboratory of Pediatrics, Pediatric Infectious Diseases Group, Erasmus MC - Sophia, Rotterdam, The Netherlands
⨯

Increased CD4⁺ T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?

Michiel van der Flier,
Dyana B. Sharma,
Silvia Estevão,
Marieke Emonts,
Denise Rook,
Jan A. Hazelzet,
Johannes B. van Goudoever,
Nico G. Hartwig

Published: July 22, 2013
https://doi.org/10.1371/journal.pone.0068294

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Neonatal sepsis
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Sepsis
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T cells
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Immune receptors
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Immune suppression
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Inflammation
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