An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo

Takashi Majima; Keisuke Takeuchi; Keigo Sano; Masanori Hirashima; Dimitar P. Zankov; Miki Tanaka-Okamoto; Hiroyoshi Ishizaki; Jun Miyoshi; Hisakazu Ogita

doi:10.1371/journal.pone.0068134

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Open Access

Peer-reviewed

Research Article

An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo

Takashi Majima ,

Contributed equally to this work with: Takashi Majima, Keisuke Takeuchi

Current address: Department of Clinical Pharmaceutics, School of Pharmaceutical Science, Ohu University, Fukushima, Japan

Affiliation Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan
⨯
Keisuke Takeuchi ,

Contributed equally to this work with: Takashi Majima, Keisuke Takeuchi

Affiliation Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Shiga, Japan
⨯
Keigo Sano,

Affiliation Division of Vascular Biology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Hyogo, Japan
⨯
Masanori Hirashima,

Affiliation Division of Vascular Biology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Hyogo, Japan
⨯
Dimitar P. Zankov,

Affiliation Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Shiga, Japan
⨯
Miki Tanaka-Okamoto,

Affiliation Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan
⨯
Hiroyoshi Ishizaki,

Affiliation Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan
⨯
Jun Miyoshi,

Affiliation Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan
⨯
Hisakazu Ogita

* E-mail: hogita@belle.shiga-med.ac.jp

Affiliation Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science, Shiga, Japan
⨯

An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo

Takashi Majima,
Keisuke Takeuchi,
Keigo Sano,
Masanori Hirashima,
Dimitar P. Zankov,
Miki Tanaka-Okamoto,
Hiroyoshi Ishizaki,
Jun Miyoshi,
Hisakazu Ogita

Published: June 26, 2013
https://doi.org/10.1371/journal.pone.0068134

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