Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease

Open Access

Peer-reviewed

Research Article

Kathryn J. Hilton,

Affiliation School of Biological Sciences, Southampton General Hospital, Southampton, United Kingdom
⨯
Colm Cunningham ,

* E-mail: colm.cunningham@tcd.ie

Affiliation Trinity College Institute of Neuroscience & School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
⨯
Richard A. Reynolds,

Affiliation School of Biological Sciences, Southampton General Hospital, Southampton, United Kingdom
⨯
V. Hugh Perry

Affiliation School of Biological Sciences, Southampton General Hospital, Southampton, United Kingdom
⨯

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Hippocampus
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Prion diseases
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Astrocytes
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Microglial cells
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Animal behavior
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Glucose
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Neuronal death
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Burrowing
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