Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations

• Eliford Ngaimisi ,

  Contributed equally to this work with: Eliford Ngaimisi, Abiy Habtewold

  Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Unit of Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

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• Abiy Habtewold ,

  Contributed equally to this work with: Eliford Ngaimisi, Abiy Habtewold

  Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Pharmacology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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• Omary Minzi,

  Affiliation Unit of Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

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• Eyasu Makonnen,

  Affiliation Department of Pharmacology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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• Sabina Mugusi,

  Affiliations Venhälsan, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden, Department of Internal Medicine, Muhimbili National Hospital, Dar es Salaam Tanzania

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• Wondwossen Amogne,

  Affiliations Department of Medicine, Unit of Infectious Diseases, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden, Department of Internal Medicine, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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• Getnet Yimer,

  Affiliation Department of Pharmacology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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• Klaus-Dieter Riedel,

  Affiliation Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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• Mohammed Janabi,

  Affiliation Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

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• Getachew Aderaye,

  Affiliation Department of Internal Medicine, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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• Ferdinand Mugusi,

  Affiliation Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

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• Leif Bertilsson,

  Affiliation Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

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• Eleni Aklillu ,

  * E-mail: Eleni.Aklillu@ki.se

  ¶These authors also contributed equally to this work.

  Affiliation Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

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• Juergen Burhenne

  ¶These authors also contributed equally to this work.

  Affiliation Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany

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