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Open Access

Peer-reviewed

Research Article

DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation

Minakshi Guha ,

Contributed equally to this work with: Minakshi Guha, Elena Castellanos-Rizaldos

Affiliation Division of DNA Repair and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
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Elena Castellanos-Rizaldos ,

Contributed equally to this work with: Minakshi Guha, Elena Castellanos-Rizaldos

Affiliation Division of DNA Repair and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
G. Mike Makrigiorgos

* E-mail: mmakrigiorgos@lroc.harvard.edu

Affiliations Division of DNA Repair and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Medical Physics and Biophysics, Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation

Minakshi Guha,
Elena Castellanos-Rizaldos,
G. Mike Makrigiorgos

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Published: June 21, 2013
https://doi.org/10.1371/journal.pone.0067782

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Polymerase chain reaction
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Mutation detection
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DNA denaturation
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Cancer treatment
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Dideoxy DNA sequencing
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Non-small cell lung cancer
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DNA annealing
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Mutation
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