Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion during Acute Sepsis in Non-Diabetic Mice

Yoshio Watanabe; Srikanth Singamsetty; Baobo Zou; Lanping Guo; Darko Stefanovski; Laura C. Alonso; Adolfo Garcia-Ocana; Christopher P. O’Donnell; Bryan J. McVerry

doi:10.1371/journal.pone.0067716

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Open Access

Peer-reviewed

Research Article

Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion during Acute Sepsis in Non-Diabetic Mice

Yoshio Watanabe ,

Contributed equally to this work with: Yoshio Watanabe, Srikanth Singamsetty

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Srikanth Singamsetty ,

Contributed equally to this work with: Yoshio Watanabe, Srikanth Singamsetty

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Baobo Zou,

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Lanping Guo,

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Darko Stefanovski,

Affiliation Department of Biomedical Sciences, Cedars Sinai Medical Center, University of California Los Angeles, Los Angeles, California, United States of America
⨯
Laura C. Alonso,

Affiliation Division of Endocrinology and Metabolism University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Adolfo Garcia-Ocana,

Affiliation Division of Endocrinology and Metabolism University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Christopher P. O’Donnell,

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Bryan J. McVerry

* E-mail: mcverrybj@upmc.edu

Affiliation Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion during Acute Sepsis in Non-Diabetic Mice

Yoshio Watanabe,
Srikanth Singamsetty,
Baobo Zou,
Lanping Guo,
Darko Stefanovski,
Laura C. Alonso,
Adolfo Garcia-Ocana,
Christopher P. O’Donnell,
Bryan J. McVerry

Published: June 24, 2013
https://doi.org/10.1371/journal.pone.0067716

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Glucose
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