Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore?

• Rajkumar Dorajoo ,

  Contributed equally to this work with: Rajkumar Dorajoo, Ruoying Li

  Affiliation Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

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• Ruoying Li ,

  Contributed equally to this work with: Rajkumar Dorajoo, Ruoying Li

  Affiliation Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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• Mohammad Kamran Ikram,

  Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore, Department of Epidemiology and Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Jianjun Liu,

  Affiliation Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

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• Philippe Froguel,

  Affiliations Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom, CNRS-UMR-8199, Univ Lille Nord de France, UDSL, Lille, France

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• Jeannette Lee,

  Affiliation Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore

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• Xueling Sim,

  Affiliations Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore, Centre for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Rick Twee-Hee Ong,

  Affiliations Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, National University of Singapore Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore

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• Wan Ting Tay,

  Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

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• Chen Peng,

  Affiliation Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore

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• Terri L. Young,

  Affiliations Duke–National University of Singapore Graduate Medical School, Singapore, Singapore, Duke Centre for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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• Alexandra I. F. Blakemore,

  Affiliation Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, United Kingdom

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• Ching Yu Cheng,

  Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore

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• Tin Aung,

  Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

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• Paul Mitchell,

  Affiliation Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia

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• Jie Jin Wang,

  Affiliations Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia, Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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• Caroline C. Klaver,

  Affiliation Department of Epidemiology and Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Eric Boerwinkle,

  Affiliation Human Genetics Center and Human Genome Sequencing Center, University of Texas and Baylor College of Medicine, Houston, Texas, United States of America

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• Ronald Klein,

  Affiliation Department of Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States of America

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• David S. Siscovick,

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

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• Richard A. Jensen,

  Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Vilmundur Gudnason,

  Affiliations Department of Medicine, University of Iceland, Reykjavik, Iceland, Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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• Albert Vernon Smith,

  Affiliation Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

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• Yik Ying Teo ,

  * E-mail: statyy@nus.edu.sg (YYT); tien_yin_wong@nuhs.edu.sg (TYW)); e_shyong_tai@nuhs.edu.sg (EST); chew_kiat_heng@nuhs.edu.sg (CKH); yechielf@ekmd.huji.ac.il (YF)

  Affiliations Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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• Tien Yin Wong ,

  * E-mail: statyy@nus.edu.sg (YYT); tien_yin_wong@nuhs.edu.sg (TYW)); e_shyong_tai@nuhs.edu.sg (EST); chew_kiat_heng@nuhs.edu.sg (CKH); yechielf@ekmd.huji.ac.il (YF)

  Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

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• E-Shyong Tai ,

  * E-mail: statyy@nus.edu.sg (YYT); tien_yin_wong@nuhs.edu.sg (TYW)); e_shyong_tai@nuhs.edu.sg (EST); chew_kiat_heng@nuhs.edu.sg (CKH); yechielf@ekmd.huji.ac.il (YF)

  Affiliations Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Duke–National University of Singapore Graduate Medical School, Singapore, Singapore

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• Chew-Kiat Heng ,

  * E-mail: statyy@nus.edu.sg (YYT); tien_yin_wong@nuhs.edu.sg (TYW)); e_shyong_tai@nuhs.edu.sg (EST); chew_kiat_heng@nuhs.edu.sg (CKH); yechielf@ekmd.huji.ac.il (YF)

  Affiliation Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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•  [ ... ],
• Yechiel Friedlander

  * E-mail: statyy@nus.edu.sg (YYT); tien_yin_wong@nuhs.edu.sg (TYW)); e_shyong_tai@nuhs.edu.sg (EST); chew_kiat_heng@nuhs.edu.sg (CKH); yechielf@ekmd.huji.ac.il (YF)

  Affiliation Epidemiology Unit, Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel

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