Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

Xiaojun Wang; Ryosuke Misawa; Mark C. Zielinski; Peter Cowen; Junghyo Jo; Vipul Periwal; Camillo Ricordi; Aisha Khan; Joel Szust; Junhui Shen; J. Michael Millis; Piotr Witkowski; Manami Hara

doi:10.1371/journal.pone.0067454

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Open Access

Peer-reviewed

Research Article

Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

Xiaojun Wang,

Affiliations Department of Surgery, The University of Chicago, Chicago, Illinois, United States of America, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Ryosuke Misawa,

Current address: Cell Transplant Center, University of Miami, Miami, Florida, United States of America

Affiliation Department of Surgery, The University of Chicago, Chicago, Illinois, United States of America
⨯
Mark C. Zielinski,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Peter Cowen,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Junghyo Jo,

Current address: Asia Pacific Center for Theoretical Physics, Gyeongbuk, Korea

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Vipul Periwal,

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Camillo Ricordi,

Affiliation Cell Transplant Center, University of Miami, Miami, Florida, United States of America
⨯
Aisha Khan,

Affiliation Cell Transplant Center, University of Miami, Miami, Florida, United States of America
⨯
Joel Szust,

Affiliation Cell Transplant Center, University of Miami, Miami, Florida, United States of America
⨯
Junhui Shen,

Current address: Laboratory of Clinical Visual Science, Tongji University School of Medicine, Shanghai, China

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
J. Michael Millis,

Affiliation Department of Surgery, The University of Chicago, Chicago, Illinois, United States of America
⨯
Piotr Witkowski,

Affiliation Department of Surgery, The University of Chicago, Chicago, Illinois, United States of America
⨯
Manami Hara

* E-mail: mhara@uchicago.edu

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯

Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

Xiaojun Wang,
Ryosuke Misawa,
Mark C. Zielinski,
Peter Cowen,
Junghyo Jo,
Vipul Periwal,
Camillo Ricordi,
Aisha Khan,
Joel Szust,
Junhui Shen

Published: June 24, 2013
https://doi.org/10.1371/journal.pone.0067454

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