Lin28 Mediates Radiation Resistance of Breast Cancer Cells via Regulation of Caspase, H2A.X and Let-7 Signaling

Linbo Wang; Chao Yuan; Kezhen Lv; Shuduo Xie; Peifen Fu; Xiaojiao Liu; Yongxia Chen; Chuan Qin; Wuguo Deng; Wenxian Hu

doi:10.1371/journal.pone.0067373

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Open Access

Peer-reviewed

Research Article

Lin28 Mediates Radiation Resistance of Breast Cancer Cells via Regulation of Caspase, H2A.X and Let-7 Signaling

Linbo Wang ,

Contributed equally to this work with: Linbo Wang, Chao Yuan

Affiliation Key Laboratory of Biotherapy of Zhejiang Province, Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Chao Yuan ,

Contributed equally to this work with: Linbo Wang, Chao Yuan

Affiliation Key Laboratory of Biotherapy of Zhejiang Province, Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Kezhen Lv,

Affiliation Department of Breast Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Shuduo Xie,

Affiliation Key Laboratory of Biotherapy of Zhejiang Province, Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Peifen Fu,

Affiliation Department of Breast Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Xiaojiao Liu,

Affiliation Department of Breast Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Yongxia Chen,

Affiliation Key Laboratory of Biotherapy of Zhejiang Province, Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Chuan Qin,

Affiliation Key Laboratory of Biotherapy of Zhejiang Province, Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯
Wuguo Deng ,

* E-mail: hwx2206@hotmail.com (WH); dengwg@hotmail.com (WD)

Affiliations Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Wenxian Hu

* E-mail: hwx2206@hotmail.com (WH); dengwg@hotmail.com (WD)

Affiliation Key Laboratory of Biotherapy of Zhejiang Province, Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⨯

Lin28 Mediates Radiation Resistance of Breast Cancer Cells via Regulation of Caspase, H2A.X and Let-7 Signaling

Linbo Wang,
Chao Yuan,
Kezhen Lv,
Shuduo Xie,
Peifen Fu,
Xiaojiao Liu,
Yongxia Chen,
Chuan Qin,
Wuguo Deng,
Wenxian Hu

Published: June 20, 2013
https://doi.org/10.1371/journal.pone.0067373

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