An HIV-1 Envelope Glycoprotein Trimer with an Embedded IL-21 Domain Activates Human B Cells

• Gözde Isik,

  Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Nancy P. Y. Chung,

  Affiliation Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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• Thijs van Montfort,

  Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Sergey Menis,

  Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, IAVI Neutralizing Antibody Center and Department of Immunology and Microbial Sciences, The Scripps Research Institute, San Diego, California, United States of America

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• Katie Matthews,

  Affiliation Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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• William R. Schief,

  Affiliations Department of Immunology and Microbial Science, The Scripps Research Institute, San Diego, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, San Diego, California, United States of America, Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, San Diego, California, United States of America

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• John P. Moore,

  Affiliation Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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• Rogier W. Sanders

  * E-mail: r.w.sanders@amc.uva.nl

  Affiliations Laboratory of Experimental Virology, Department of Medical Microbiology Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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