Intron Retention in mRNA Encoding Ancillary Subunit of Insect Voltage-Gated Sodium Channel Modulates Channel Expression, Gating Regulation and Drug Sensitivity

Céline M. Bourdin; Bénédicte Moignot; Lingxin Wang; Laurence Murillo; Marjorie Juchaux; Sophie Quinchard; Bruno Lapied; Nathalie C. Guérineau; Ke Dong; Christian Legros

doi:10.1371/journal.pone.0067290

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Research Article

Intron Retention in mRNA Encoding Ancillary Subunit of Insect Voltage-Gated Sodium Channel Modulates Channel Expression, Gating Regulation and Drug Sensitivity

Céline M. Bourdin,

Affiliation Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM) UPRES EA 2647/USC INRA 1330, SFR QUASAV 4207, UFR Sciences, Université d'Angers, Angers, France
⨯
Bénédicte Moignot,

Affiliation Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM) UPRES EA 2647/USC INRA 1330, SFR QUASAV 4207, UFR Sciences, Université d'Angers, Angers, France
⨯
Lingxin Wang,

Affiliation Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, Michigan, United States of America
⨯
Laurence Murillo,

Affiliations Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM) UPRES EA 2647/USC INRA 1330, SFR QUASAV 4207, UFR Sciences, Université d'Angers, Angers, France, Laboratoire LIttoral ENvironnement et Sociétés (LIENSs), UMR 7266 CNRS, Institut du Littoral et de l'Environnement, Université de La Rochelle, La Rochelle, France
⨯
Marjorie Juchaux,

Affiliation IMAC, SFR QUASAV 4207, Université d'Angers, Beaucouzé, France
⨯
Sophie Quinchard,

Affiliation Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM) UPRES EA 2647/USC INRA 1330, SFR QUASAV 4207, UFR Sciences, Université d'Angers, Angers, France
⨯
Bruno Lapied,

Affiliation Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM) UPRES EA 2647/USC INRA 1330, SFR QUASAV 4207, UFR Sciences, Université d'Angers, Angers, France
⨯
Nathalie C. Guérineau,

Affiliation Laboratoire de Biologie Neurovasculaire et Mitochondriale Intégrée, UMR CNRS 6214, INSERM 1083, UFR de Sciences Médicales, Université d'Angers, Angers, France
⨯
Ke Dong,

Affiliation Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, Michigan, United States of America
⨯
Christian Legros

* E-mail: christian.legros@univ-angers.fr

Affiliations Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM) UPRES EA 2647/USC INRA 1330, SFR QUASAV 4207, UFR Sciences, Université d'Angers, Angers, France, Laboratoire de Biologie Neurovasculaire et Mitochondriale Intégrée, UMR CNRS 6214, INSERM 1083, UFR de Sciences Médicales, Université d'Angers, Angers, France
⨯

Intron Retention in mRNA Encoding Ancillary Subunit of Insect Voltage-Gated Sodium Channel Modulates Channel Expression, Gating Regulation and Drug Sensitivity

Céline M. Bourdin,
Bénédicte Moignot,
Lingxin Wang,
Laurence Murillo,
Marjorie Juchaux,
Sophie Quinchard,
Bruno Lapied,
Nathalie C. Guérineau,
Ke Dong,
Christian Legros

Published: August 15, 2013
https://doi.org/10.1371/journal.pone.0067290

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Introns
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