Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response

Jenny Carmona; Andrea Cruz; Lucia Moreira-Teixeira; Carole Sousa; Jeremy Sousa; Nuno S. Osorio; Ana L. Saraiva; Stefan Svenson; Gunilla Kallenius; Jorge Pedrosa; Fernando Rodrigues; Antonio G. Castro; Margarida Saraiva

doi:10.1371/journal.pone.0067277

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Open Access

Peer-reviewed

Research Article

Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response

Jenny Carmona,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Andrea Cruz,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Lucia Moreira-Teixeira,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Carole Sousa,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Jeremy Sousa,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Nuno S. Osorio,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Ana L. Saraiva,

Affiliation Escola Universitária Vasco da Gama (EUVG), Coimbra, Portugal
⨯
Stefan Svenson,

Affiliation Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden
⨯
Gunilla Kallenius,

Affiliation Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden
⨯
Jorge Pedrosa,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Fernando Rodrigues,

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Antonio G. Castro ,

* E-mail: acastro@ecsaude.uminho.pt (AGC); msaraiva@ecsaude.uminho.pt (MS)

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯
Margarida Saraiva

* E-mail: acastro@ecsaude.uminho.pt (AGC); msaraiva@ecsaude.uminho.pt (MS)

Affiliations Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal
⨯

Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response

Jenny Carmona,
Andrea Cruz,
Lucia Moreira-Teixeira,
Carole Sousa,
Jeremy Sousa,
Nuno S. Osorio,
Ana L. Saraiva,
Stefan Svenson,
Gunilla Kallenius,
Jorge Pedrosa

Published: June 26, 2013
https://doi.org/10.1371/journal.pone.0067277

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Mycobacterium tuberculosis
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Cytokines
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Macrophages
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Immune response
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Tuberculosis
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Immune receptor signaling
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Extensively drug-resistant tuberculosis
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Immunoassays
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