Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation

• Douglas D. Fang,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Cathy C. Zhang ,

  * E-mail: cathy.zhang@pfizer.com

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Yin Gu,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Jitesh P. Jani,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Joan Cao,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Konstantinos Tsaparikos,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Jing Yuan,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Melissa Thiel,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Amy Jackson-Fisher,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Qing Zong,

  Affiliation Drug Safety Research and Development, Pfizer Global Research & Development, San Diego, California, United States of America

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• Patrick B. Lappin,

  Affiliation Drug Safety Research and Development, Pfizer Global Research & Development, San Diego, California, United States of America

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• Tomoko Hayashi,

  Affiliation Moores UCSD Cancer Center, University of California San Diego, San Diego, California, United States of America

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• Richard B. Schwab,

  Affiliation Moores UCSD Cancer Center, University of California San Diego, San Diego, California, United States of America

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• Anthony Wong,

  Affiliation Drug Safety Research and Development, Pfizer Global Research & Development, San Diego, California, United States of America

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• Annette John-Baptiste,

  Affiliation Drug Safety Research and Development, Pfizer Global Research & Development, San Diego, California, United States of America

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• Shubha Bagrodia,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Geritt Los,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• Steve Bender,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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• James Christensen,

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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•  [ ... ],
• Todd VanArsdale

  Affiliation Oncology Research Unit, Pfizer Global Research & Development, San Diego, California, United States of America

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