Layered Signaling Regulatory Networks Analysis of Gene Expression Involved in Malignant Tumorigenesis of Non-Resolving Ulcerative Colitis via Integration of Cross-Study Microarray Profiles

Shengjun Fan; Zhenyu Pan; Qiang Geng; Xin Li; Yefan Wang; Yu An; Yan Xu; Lu Tie; Yan Pan; Xuejun Li

doi:10.1371/journal.pone.0067142

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Peer-reviewed

Research Article

Layered Signaling Regulatory Networks Analysis of Gene Expression Involved in Malignant Tumorigenesis of Non-Resolving Ulcerative Colitis via Integration of Cross-Study Microarray Profiles

Shengjun Fan,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China
⨯
Zhenyu Pan,

Affiliation Department of Pharmacy, Xi’an Children’s Hospital, Xi’an, China
⨯
Qiang Geng,

Affiliation Department of Cardiology, Peking University People’s Hospital, Beijing, China
⨯
Xin Li,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China
⨯
Yefan Wang,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China
⨯
Yu An,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China
⨯
Yan Xu,

Affiliation Pediatric Research Institute, Qilu Children’s Hospital of Shandong University, Jinan, China
⨯
Lu Tie,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China
⨯
Yan Pan,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China
⨯
Xuejun Li

* E-mail: xjli@bjmu.edu.cn

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China
⨯

Layered Signaling Regulatory Networks Analysis of Gene Expression Involved in Malignant Tumorigenesis of Non-Resolving Ulcerative Colitis via Integration of Cross-Study Microarray Profiles

Shengjun Fan,
Zhenyu Pan,
Qiang Geng,
Xin Li,
Yefan Wang,
Yu An,
Yan Xu,
Lu Tie,
Yan Pan,
Xuejun Li

Published: June 25, 2013
https://doi.org/10.1371/journal.pone.0067142

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Colorectal cancer
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Signaling networks
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Microarrays
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Gene expression
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