Cobalt-Alloy Implant Debris Induce HIF-1α Hypoxia Associated Responses: A Mechanism for Metal-Specific Orthopedic Implant Failure

Open Access

Peer-reviewed

Research Article

Lauryn Samelko,

Affiliations Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America, Department of Immunology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Marco S. Caicedo,

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Seung-Jae Lim,

Affiliation Department of Orthopedic Surgery, Samsung Medical Center, Seoul, Korea
⨯
Craig Della-Valle,

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
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Joshua Jacobs,

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Nadim J. Hallab

* E-mail: nhallab@rush.edu

Affiliation Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America
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Macrophages
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Medical hypoxia
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Medical implants
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Enzyme-linked immunoassays
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Inflammation
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Protein expression
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Cobalt
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Cobalt alloys
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