P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

France Massicot; Guillaume Hache; Ludivine David; Dominique Chen; Charlotte Leuxe; Laure Garnier-Legrand; Patrice Rat; Olivier Laprévote; François Coudoré

doi:10.1371/journal.pone.0066830

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Peer-reviewed

Research Article

P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

France Massicot ,

* E-mail: france.massicot@parisdescartes.fr

Affiliation Laboratoire de Chimie-Toxicologie Analytique et Cellulaire, EA4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
⨯
Guillaume Hache,

Affiliation Laboratoire de NeuroPharmacologie, EA3544, Faculté de Pharmacie, Université Paris Sud 11, PRES Paris-Saclay, Chatenay-Malabry, France
⨯
Ludivine David,

Affiliation Laboratoire de Chimie-Toxicologie Analytique et Cellulaire, EA4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
⨯
Dominique Chen,

Affiliation Laboratoire de Chimie-Toxicologie Analytique et Cellulaire, EA4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
⨯
Charlotte Leuxe,

Affiliation Laboratoire de Chimie-Toxicologie Analytique et Cellulaire, EA4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
⨯
Laure Garnier-Legrand,

Affiliation Laboratoire de Chimie-Toxicologie Analytique et Cellulaire, EA4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
⨯
Patrice Rat,

Affiliation Laboratoire de Chimie-Toxicologie Analytique et Cellulaire, EA4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
⨯
Olivier Laprévote,

Affiliation Laboratoire de Chimie-Toxicologie Analytique et Cellulaire, EA4463, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
⨯
François Coudoré

Affiliation Laboratoire de NeuroPharmacologie, EA3544, Faculté de Pharmacie, Université Paris Sud 11, PRES Paris-Saclay, Chatenay-Malabry, France
⨯

P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

France Massicot,
Guillaume Hache,
Ludivine David,
Dominique Chen,
Charlotte Leuxe,
Laure Garnier-Legrand,
Patrice Rat,
Olivier Laprévote,
François Coudoré

Published: June 27, 2013
https://doi.org/10.1371/journal.pone.0066830

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