Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD

• Johannes Rotta detto Loria ,

  Contributed equally to this work with: Johannes Rotta detto Loria, Kristina Rohmann

  * E-mail: johannes.rottadettoloria@medizin.uni-luebeck.de

  Affiliation Medical Clinic III, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

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• Kristina Rohmann ,

  Contributed equally to this work with: Johannes Rotta detto Loria, Kristina Rohmann

  Affiliation Medical Clinic III, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

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• Daniel Droemann,

  Affiliation Medical Clinic III, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

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• Peter Kujath,

  Affiliation Department of Surgery/Thoracic Surgery, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

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• Jan Rupp,

  Affiliations Medical Clinic III, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany, Institute of Medical Microbiology and Hygiene, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

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• Torsten Goldmann,

  Affiliations Clinical and Experimental Pathology, Research Center Borstel, Borstel, Germany, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany

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• Klaus Dalhoff

  Affiliations Medical Clinic III, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany

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