Advanced Glycation End Products Induce Human Corneal Epithelial Cells Apoptosis through Generation of Reactive Oxygen Species and Activation of JNK and p38 MAPK Pathways

Open Access

Peer-reviewed

Research Article

Long Shi ,

Contributed equally to this work with: Long Shi, Xiaoming Yu

Affiliations Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China
⨯
Xiaoming Yu ,

Contributed equally to this work with: Long Shi, Xiaoming Yu

Affiliations Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China
⨯
Hongling Yang,

Affiliation Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China
⨯
Xinyi Wu

* E-mail: xywu8868@163.com

Affiliation Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China
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Apoptosis
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Diabetes mellitus
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Cornea
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Protein expression
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MAPK signaling cascades
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Epithelial cells
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Reactive oxygen species
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Glycation
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