Epitope Mapping of M36, a Human Antibody Domain with Potent and Broad HIV-1 Inhibitory Activity

Chao Wan; Jianping Sun; Weizao Chen; Xiaohui Yuan; Huihui Chong; Ponraj Prabakaran; Dimiter S. Dimitrov; Yuxian He

doi:10.1371/journal.pone.0066638

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Open Access

Peer-reviewed

Research Article

Epitope Mapping of M36, a Human Antibody Domain with Potent and Broad HIV-1 Inhibitory Activity

Chao Wan ,

Contributed equally to this work with: Chao Wan, Jianping Sun

Affiliation MOH Key Laboratory of Systems Biology of Pathogens and AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jianping Sun ,

Contributed equally to this work with: Chao Wan, Jianping Sun

Affiliation MOH Key Laboratory of Systems Biology of Pathogens and AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Weizao Chen,

Affiliation Protein Interactions Group, CCRNP, CCR, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
⨯
Xiaohui Yuan,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens and AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Huihui Chong,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens and AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Ponraj Prabakaran,

Affiliation Protein Interactions Group, CCRNP, CCR, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
⨯
Dimiter S. Dimitrov,

Affiliation Protein Interactions Group, CCRNP, CCR, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
⨯
Yuxian He

* E-mail: yhe@ipb.pumc.edu.cn

Affiliation MOH Key Laboratory of Systems Biology of Pathogens and AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

Epitope Mapping of M36, a Human Antibody Domain with Potent and Broad HIV-1 Inhibitory Activity

Chao Wan,
Jianping Sun,
Weizao Chen,
Xiaohui Yuan,
Huihui Chong,
Ponraj Prabakaran,
Dimiter S. Dimitrov,
Yuxian He

Published: June 11, 2013
https://doi.org/10.1371/journal.pone.0066638

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HIV-1
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Antibodies
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Phage display
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Molecular docking
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Enzyme-linked immunoassays
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Peptide libraries
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Coreceptors
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Epitope mapping
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