Coverage Bias and Sensitivity of Variant Calling for Four Whole-genome Sequencing Technologies

• Nora Rieber ,

  Contributed equally to this work with: Nora Rieber, Marc Zapatka

  Affiliation Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Marc Zapatka ,

  Contributed equally to this work with: Nora Rieber, Marc Zapatka

  Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Bärbel Lasitschka,

  Affiliation Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• David Jones,

  Affiliation Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Paul Northcott,

  Affiliation The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children Research Institute, University of Toronto, Ontario, Canada

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• Barbara Hutter,

  Affiliation Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Natalie Jäger,

  Affiliation Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Marcel Kool,

  Affiliation Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Michael Taylor,

  Affiliations The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children Research Institute, University of Toronto, Ontario, Canada, Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada

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• Peter Lichter,

  Affiliation Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Stefan Pfister,

  Affiliations Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany

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• Stephan Wolf,

  Affiliation Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Benedikt Brors,

  Affiliation Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Roland Eils

  * E-mail: r.eils@dkfz.de

  Affiliations Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, and Bioquant, University of Heidelberg, Heidelberg, Germany

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