The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice

Arpana Sali; Gina M. Many; Heather Gordish-Dressman; Jack H. van der Meulen; Aditi Phadke; Christopher F. Spurney; Avital Cnaan; Eric P. Hoffman; Kanneboyina Nagaraju

doi:10.1371/journal.pone.0066617

Loading metrics

Open Access

Peer-reviewed

Research Article

The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice

Arpana Sali,

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯
Gina M. Many,

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯
Heather Gordish-Dressman,

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯
Jack H. van der Meulen,

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯
Aditi Phadke,

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯
Christopher F. Spurney,

Affiliations Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America, Division of Cardiology, Children’s National Medical Center, Washington, DC, United States of America
⨯
Avital Cnaan,

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯
Eric P. Hoffman,

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯
Kanneboyina Nagaraju

* E-mail: knagaraju@cnmcresearch.org

Affiliation Center for Genetic Medicine Research, Children’s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America
⨯

The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice

Arpana Sali,
Gina M. Many,
Heather Gordish-Dressman,
Jack H. van der Meulen,
Aditi Phadke,
Christopher F. Spurney,
Avital Cnaan,
Eric P. Hoffman,
Kanneboyina Nagaraju

Published: July 2, 2013
https://doi.org/10.1371/journal.pone.0066617

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Hand strength
Is the Subject Area "Hand strength" applicable to this article?

Thanks for your feedback.
Skeletal muscles
Is the Subject Area "Skeletal muscles" applicable to this article?

Thanks for your feedback.
Musculoskeletal mechanics
Is the Subject Area "Musculoskeletal mechanics" applicable to this article?

Thanks for your feedback.
Muscle contraction
Is the Subject Area "Muscle contraction" applicable to this article?

Thanks for your feedback.
Histology
Is the Subject Area "Histology" applicable to this article?

Thanks for your feedback.
Glucocorticoid therapy
Is the Subject Area "Glucocorticoid therapy" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.