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Open Access

Peer-reviewed

Research Article

An RGD-Modified MRI-Visible Polymeric Vector for Targeted siRNA Delivery to Hepatocellular Carcinoma in Nude Mice

Chun Wu ,

Contributed equally to this work with: Chun Wu, Faming Gong, Pengfei Pang

Affiliations Molecular Imaging Lab, Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Interventional Radiology Institute, Sun Yat-sen University, Guangzhou, China
⨯
Faming Gong ,

Contributed equally to this work with: Chun Wu, Faming Gong, Pengfei Pang

Affiliation PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
⨯
Pengfei Pang ,

Contributed equally to this work with: Chun Wu, Faming Gong, Pengfei Pang

Affiliations Molecular Imaging Lab, Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Interventional Radiology Institute, Sun Yat-sen University, Guangzhou, China
⨯
Min Shen,

Affiliations Molecular Imaging Lab, Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Interventional Radiology Institute, Sun Yat-sen University, Guangzhou, China
⨯
Kangshun Zhu,

Affiliations Molecular Imaging Lab, Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Interventional Radiology Institute, Sun Yat-sen University, Guangzhou, China
⨯
Du Cheng,

Affiliation PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
⨯
Zhihao Liu,

Affiliation Molecular Digestive Lab, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
⨯
Hong Shan

* E-mail: shanhong@mail.sysu.edu.cn

Affiliations Molecular Imaging Lab, Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Interventional Radiology Institute, Sun Yat-sen University, Guangzhou, China
⨯

An RGD-Modified MRI-Visible Polymeric Vector for Targeted siRNA Delivery to Hepatocellular Carcinoma in Nude Mice

Chun Wu,
Faming Gong,
Pengfei Pang,
Min Shen,
Kangshun Zhu,
Du Cheng,
Zhihao Liu,
Hong Shan

x

Published: June 7, 2013
https://doi.org/10.1371/journal.pone.0066416

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Small interfering RNA
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Cancers and neoplasms
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Hepatocellular carcinoma
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Apoptosis
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Magnetic resonance imaging
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Transfection
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Fluorescence imaging
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Cancer treatment
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