Low Molecular Weight Heparin Relieves Experimental Colitis in Mice by Downregulating IL-1β and Inhibiting Syndecan-1 Shedding in the Intestinal Mucosa

Xian-fei Wang; Ai-ming Li; Jing Li; Shi-yong Lin; Chu-di Chen; You-lian Zhou; Xia Wang; Cun-long Chen; Si-de Liu; Ye Chen

doi:10.1371/journal.pone.0066397

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Open Access

Peer-reviewed

Research Article

Low Molecular Weight Heparin Relieves Experimental Colitis in Mice by Downregulating IL-1β and Inhibiting Syndecan-1 Shedding in the Intestinal Mucosa

Xian-fei Wang,

Affiliations Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
⨯
Ai-ming Li,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Jing Li,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Shi-yong Lin,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Chu-di Chen,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
You-lian Zhou,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Xia Wang,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Cun-long Chen,

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Si-de Liu ,

* E-mail: liuside2011@163.com (SDL); chenye2001@hotmail.com (YC)

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯
Ye Chen

* E-mail: liuside2011@163.com (SDL); chenye2001@hotmail.com (YC)

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⨯

Low Molecular Weight Heparin Relieves Experimental Colitis in Mice by Downregulating IL-1β and Inhibiting Syndecan-1 Shedding in the Intestinal Mucosa

Xian-fei Wang,
Ai-ming Li,
Jing Li,
Shi-yong Lin,
Chu-di Chen,
You-lian Zhou,
Xia Wang,
Cun-long Chen,
Si-de Liu,
Ye Chen

Published: July 18, 2013
https://doi.org/10.1371/journal.pone.0066397

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