Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia

Baohu Ji; Xin Wang; Antonio Pinto-Duarte; Minjung Kim; Sorana Caldwell; Jared W. Young; Margarita M. Behrens; Terrence J. Sejnowski; Mark A. Geyer; Xianjin Zhou

doi:10.1371/journal.pone.0066327

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Open Access

Peer-reviewed

Research Article

Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia

Baohu Ji ,

Contributed equally to this work with: Baohu Ji, Xin Wang

Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯
Xin Wang ,

Contributed equally to this work with: Baohu Ji, Xin Wang

Affiliation Salk Institute for Biological Studies and Howard Hughes Medical Institute, La Jolla, California, United States of America
⨯
Antonio Pinto-Duarte,

Affiliations Salk Institute for Biological Studies and Howard Hughes Medical Institute, La Jolla, California, United States of America, Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal, Neurosciences Unit, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal
⨯
Minjung Kim,

Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯
Sorana Caldwell,

Affiliations Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, Research Service, VA San Diego Healthcare System, San Diego, California, United States of America
⨯
Jared W. Young,

Affiliations Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, Research Service, VA San Diego Healthcare System, San Diego, California, United States of America
⨯
Margarita M. Behrens,

Affiliation Salk Institute for Biological Studies and Howard Hughes Medical Institute, La Jolla, California, United States of America
⨯
Terrence J. Sejnowski,

Affiliation Salk Institute for Biological Studies and Howard Hughes Medical Institute, La Jolla, California, United States of America
⨯
Mark A. Geyer,

Affiliations Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, Research Service, VA San Diego Healthcare System, San Diego, California, United States of America
⨯
Xianjin Zhou

* E-mail: xzhou@ucsd.edu

Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯

Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia

Baohu Ji,
Xin Wang,
Antonio Pinto-Duarte,
Minjung Kim,
Sorana Caldwell,
Jared W. Young,
Margarita M. Behrens,
Terrence J. Sejnowski,
Mark A. Geyer,
Xianjin Zhou

Published: June 18, 2013
https://doi.org/10.1371/journal.pone.0066327

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