Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs

Ciaran Skerry; Supriya Pokkali; Michael Pinn; Nicholas A. Be; Jamie Harper; Petros C. Karakousis; Sanjay K. Jain

doi:10.1371/journal.pone.0066310

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Research Article

Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs

Ciaran Skerry,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Supriya Pokkali,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Michael Pinn,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Nicholas A. Be,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America
⨯
Jamie Harper,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Petros C. Karakousis,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Sanjay K. Jain

* E-mail: sjain5@jhmi.edu

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs

Ciaran Skerry,
Supriya Pokkali,
Michael Pinn,
Nicholas A. Be,
Jamie Harper,
Petros C. Karakousis,
Sanjay K. Jain

Published: June 11, 2013
https://doi.org/10.1371/journal.pone.0066310

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