Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Hafumi Nishi; Manoj Tyagi; Shaolei Teng; Benjamin A. Shoemaker; Kosuke Hashimoto; Emil Alexov; Stefan Wuchty; Anna R. Panchenko

doi:10.1371/journal.pone.0066273

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Open Access

Peer-reviewed

Research Article

Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Hafumi Nishi,

Current address: Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

Affiliation National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Manoj Tyagi,

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Shaolei Teng,

Affiliation Computational Biophysics and Bioinformatics, Department of Physics, Clemson University, Clemson, South Carolina, United States of America
⨯
Benjamin A. Shoemaker,

Affiliation National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kosuke Hashimoto,

Affiliation Omics Science Center, RIKEN, Yokohama, Japan
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Emil Alexov,

Affiliation Computational Biophysics and Bioinformatics, Department of Physics, Clemson University, Clemson, South Carolina, United States of America
⨯
Stefan Wuchty,

Current address: Department of Computer Science, University of Miami, Coral Gables, Florida, United States of America

Affiliation National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Anna R. Panchenko

* E-mail: panch@ncbi.nlm.nih.gov

Affiliation National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Hafumi Nishi,
Manoj Tyagi,
Shaolei Teng,
Benjamin A. Shoemaker,
Kosuke Hashimoto,
Emil Alexov,
Stefan Wuchty,
Anna R. Panchenko

Published: June 14, 2013
https://doi.org/10.1371/journal.pone.0066273

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Protein interactions
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Protein interaction networks
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Cancers and neoplasms
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Protein-protein interactions
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DNA-binding proteins
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Substitution mutation
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Glioblastoma multiforme
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Missense mutation
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