Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

Karien Bloem; Ilona M. Vuist; Arend-Jan van der Plas; Léon M. J. Knippels; Johan Garssen; Juan J. García-Vallejo; Sandra J. van Vliet; Yvette van Kooyk

doi:10.1371/journal.pone.0066266

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Peer-reviewed

Research Article

Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

Karien Bloem,

Affiliations Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands, Danone Research, Centre for Specialized Nutrition, Wageningen, The Netherlands
⨯
Ilona M. Vuist,

Affiliation Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Arend-Jan van der Plas,

Affiliation Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Léon M. J. Knippels,

Affiliations Danone Research, Centre for Specialized Nutrition, Wageningen, The Netherlands, Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands
⨯
Johan Garssen,

Affiliations Danone Research, Centre for Specialized Nutrition, Wageningen, The Netherlands, Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands
⨯
Juan J. García-Vallejo ,

Contributed equally to this work with: Juan J. García-Vallejo, Sandra J. van Vliet

Affiliation Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Sandra J. van Vliet ,

Contributed equally to this work with: Juan J. García-Vallejo, Sandra J. van Vliet

Affiliation Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Yvette van Kooyk

* E-mail: y.vankooyk@vumc.nl

Affiliation Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
⨯

Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

Karien Bloem,
Ilona M. Vuist,
Arend-Jan van der Plas,
Léon M. J. Knippels,
Johan Garssen,
Juan J. García-Vallejo,
Sandra J. van Vliet,
Yvette van Kooyk

Published: June 11, 2013
https://doi.org/10.1371/journal.pone.0066266

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