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Open Access

Peer-reviewed

Research Article

Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 Pathways

Ruchi Saxena,

Affiliation Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Vishal Chandra,

Affiliation Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Murli Manohar,

Affiliation Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Kanchan Hajela,

Affiliation Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Utsab Debnath,

Affiliation Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Yenamandra S. Prabhakar,

Affiliation Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Karan Singh Saini,

Affiliation Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Rituraj Konwar,

Affiliation Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯
Sandeep Kumar,

Affiliation Department of Surgery, King George’s Medical University, Lucknow, Uttar Pradesh, India
⨯
Kaling Megu,

Affiliation Department of Surgery, King George’s Medical University, Lucknow, Uttar Pradesh, India
⨯
Bal Gangadhar Roy,

Affiliation Institute of Nuclear Medicine and Allied Sciences, DRDO, Delhi, India
⨯
Anila Dwivedi

* E-mail: anila.dwivedi@rediffmail.com

Affiliation Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
⨯

Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 Pathways

Ruchi Saxena,
Vishal Chandra,
Murli Manohar,
Kanchan Hajela,
Utsab Debnath,
Yenamandra S. Prabhakar,
Karan Singh Saini,
Rituraj Konwar,
Sandeep Kumar,
Kaling Megu

x

Published: June 19, 2013
https://doi.org/10.1371/journal.pone.0066246

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