Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

Qian Fan; Mai Chen; Lin Zuo; Xiying Shang; Maggie Z. Huang; Michele Ciccarelli; Philip Raake; Henriette Brinks; Kurt J. Chuprun; Gerald W. Dorn II; Walter J. Koch; Erhe Gao

doi:10.1371/journal.pone.0066234

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Peer-reviewed

Research Article

Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

Qian Fan ,

Contributed equally to this work with: Qian Fan, Mai Chen

Affiliations Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Chaoyang Hospital, Capital Medical University, Beijing, China
⨯
Mai Chen ,

Contributed equally to this work with: Qian Fan, Mai Chen

Affiliations Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Xijing Hospital, The Fourth Military Medical University, Xian, China
⨯
Lin Zuo,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Xiying Shang,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Maggie Z. Huang,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Michele Ciccarelli,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Philip Raake,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Henriette Brinks,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Kurt J. Chuprun,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Gerald W. Dorn II,

Affiliation The Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Walter J. Koch,

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Erhe Gao

* E-mail: erhe.gao@temple.edu

Affiliation Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Myocardial Ablation of G Protein–Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

Qian Fan,
Mai Chen,
Lin Zuo,
Xiying Shang,
Maggie Z. Huang,
Michele Ciccarelli,
Philip Raake,
Henriette Brinks,
Kurt J. Chuprun,
Gerald W. Dorn II

Published: June 21, 2013
https://doi.org/10.1371/journal.pone.0066234

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