Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation

Haoran Guo; Wei Wei; Zhenhong Wei; Xianjun Liu; Sean L. Evans; Weiming Yang; Hong Wang; Ying Guo; Ke Zhao; Jian-Ying Zhou; Xiao-Fang Yu

doi:10.1371/journal.pone.0066201

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Open Access

Peer-reviewed

Research Article

Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation

Haoran Guo ,

Contributed equally to this work with: Haoran Guo, Wei Wei, Zhenhong Wei

Affiliations Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Wei Wei ,

Contributed equally to this work with: Haoran Guo, Wei Wei, Zhenhong Wei

Affiliations Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Zhenhong Wei ,

Contributed equally to this work with: Haoran Guo, Wei Wei, Zhenhong Wei

Affiliation Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
⨯
Xianjun Liu,

Affiliation Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
⨯
Sean L. Evans,

Affiliation Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Weiming Yang,

Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Hong Wang,

Affiliation Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
⨯
Ying Guo,

Affiliation Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
⨯
Ke Zhao,

Affiliation Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China
⨯
Jian-Ying Zhou,

Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Xiao-Fang Yu

* E-mail: xfyu@jhsph.edu

Affiliations Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯

Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation

Haoran Guo,
Wei Wei,
Zhenhong Wei,
Xianjun Liu,
Sean L. Evans,
Weiming Yang,
Hong Wang,
Ying Guo,
Ke Zhao,
Jian-Ying Zhou

Published: July 11, 2013
https://doi.org/10.1371/journal.pone.0066201

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