Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins

• Jenna L. Mueller ,

  * E-mail: jenna.mueller@duke.edu

  Affiliation Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America

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• Zachary T. Harmany,

  Affiliation Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America

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• Jeffrey K. Mito,

  Affiliation Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Stephanie A. Kennedy,

  Affiliation Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America

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• Yongbaek Kim,

  Affiliation Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul, South Korea

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• Leslie Dodd,

  Affiliation Department of Pathology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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• Joseph Geradts,

  Affiliation Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

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• David G. Kirsch,

  Affiliations Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Rebecca M. Willett,

  Affiliation Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States of America

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• J. Quincy Brown,

  Affiliation Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, United States of America

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• Nimmi Ramanujam

  Affiliation Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America

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