A Binding-Site Barrier Affects Imaging Efficiency of High Affinity Amyloid-Reactive Peptide Radiotracers In Vivo

Jonathan S. Wall; Angela Williams; Tina Richey; Alan Stuckey; Ying Huang; Craig Wooliver; Sallie Macy; Eric Heidel; Neil Gupta; Angela Lee; Brianna Rader; Emily B. Martin; Stephen J. Kennel

doi:10.1371/journal.pone.0066181

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Open Access

Peer-reviewed

Research Article

A Binding-Site Barrier Affects Imaging Efficiency of High Affinity Amyloid-Reactive Peptide Radiotracers In Vivo

Jonathan S. Wall ,

* E-mail: jwall@utmck.edu

Affiliations Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America, Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Angela Williams,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Tina Richey,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Alan Stuckey,

Affiliation Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Ying Huang,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Craig Wooliver,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Sallie Macy,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Eric Heidel,

Affiliation Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Neil Gupta,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Angela Lee,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Brianna Rader,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Emily B. Martin,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯
Stephen J. Kennel

Affiliations Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America, Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States of America
⨯

A Binding-Site Barrier Affects Imaging Efficiency of High Affinity Amyloid-Reactive Peptide Radiotracers In Vivo

Jonathan S. Wall,
Angela Williams,
Tina Richey,
Alan Stuckey,
Ying Huang,
Craig Wooliver,
Sallie Macy,
Eric Heidel,
Neil Gupta,
Angela Lee

Published: June 4, 2013
https://doi.org/10.1371/journal.pone.0066181

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Amyloid proteins
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Heparin
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