Augmented BMPRIA-Mediated BMP Signaling in Cranial Neural Crest Lineage Leads to Cleft Palate Formation and Delayed Tooth Differentiation

Lu Li; Ying Wang; Minkui Lin; Guohua Yuan; Guobin Yang; Yuqian Zheng; YiPing Chen

doi:10.1371/journal.pone.0066107

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Peer-reviewed

Research Article

Augmented BMPRIA-Mediated BMP Signaling in Cranial Neural Crest Lineage Leads to Cleft Palate Formation and Delayed Tooth Differentiation

Lu Li ,

Contributed equally to this work with: Lu Li, Ying Wang

Affiliation Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of America
⨯
Ying Wang ,

Contributed equally to this work with: Lu Li, Ying Wang

Affiliations Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of America, Department of Operative Dentistry and Endodontics, College of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi Province, P.R. China
⨯
Minkui Lin,

Affiliations Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of America, Department of Periodontology, College of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, P.R. China
⨯
Guohua Yuan,

Affiliations Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of America, Department of Pediatric Dentistry, College of Stomatology, Wuhan University, Wuhan, Hubei Province, P.R. China
⨯
Guobin Yang,

Affiliations Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of America, Department of Pediatric Dentistry, College of Stomatology, Wuhan University, Wuhan, Hubei Province, P.R. China
⨯
Yuqian Zheng,

Affiliations Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of America, Department of Periodontology, College of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, P.R. China
⨯
YiPing Chen

* E-mail: ychen@tulane.edu

Affiliation Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana, United States of America
⨯

Augmented BMPRIA-Mediated BMP Signaling in Cranial Neural Crest Lineage Leads to Cleft Palate Formation and Delayed Tooth Differentiation

Lu Li,
Ying Wang,
Minkui Lin,
Guohua Yuan,
Guobin Yang,
Yuqian Zheng,
YiPing Chen

Published: June 12, 2013
https://doi.org/10.1371/journal.pone.0066107

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BMP signaling
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Genetically modified animals
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Palate
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Cleft palate
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Teeth
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Cartilage
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Cell proliferation
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Molars
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