Calpain Inhibition Promotes the Rescue of F508del-CFTR in PBMC from Cystic Fibrosis Patients

Monica Averna; Marco Pedrazzi; Laura Minicucci; Roberta De Tullio; Federico Cresta; Franca Salamino; Sandro Pontremoli; Edon Melloni

doi:10.1371/journal.pone.0066089

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Open Access

Peer-reviewed

Research Article

Calpain Inhibition Promotes the Rescue of F⁵⁰⁸del-CFTR in PBMC from Cystic Fibrosis Patients

Monica Averna,

Affiliation Department of Experimental Medicine (DIMES) - Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy
⨯
Marco Pedrazzi,

Affiliation Department of Experimental Medicine (DIMES) - Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy
⨯
Laura Minicucci,

Affiliation Cystic Fibrosis Pediatric Center, G. Gaslini Hospital, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Science Mother and Child, University of Genoa, Genoa, Italy
⨯
Roberta De Tullio,

Affiliation Department of Experimental Medicine (DIMES) - Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy
⨯
Federico Cresta,

Affiliation Cystic Fibrosis Pediatric Center, G. Gaslini Hospital, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Science Mother and Child, University of Genoa, Genoa, Italy
⨯
Franca Salamino,

Affiliation Department of Experimental Medicine (DIMES) - Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy
⨯
Sandro Pontremoli,

Affiliation Department of Experimental Medicine (DIMES) - Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy
⨯
Edon Melloni

* E-mail: melloni@unige.it

Affiliation Department of Experimental Medicine (DIMES) - Biochemistry Section, and Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy
⨯

Calpain Inhibition Promotes the Rescue of F⁵⁰⁸del-CFTR in PBMC from Cystic Fibrosis Patients

Monica Averna,
Marco Pedrazzi,
Laura Minicucci,
Roberta De Tullio,
Federico Cresta,
Franca Salamino,
Sandro Pontremoli,
Edon Melloni

Published: June 13, 2013
https://doi.org/10.1371/journal.pone.0066089

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