A Computationally Designed Water-Soluble Variant of a G-Protein-Coupled Receptor: The Human Mu Opioid Receptor

• Jose Manuel Perez-Aguilar ,

  Contributed equally to this work with: Jose Manuel Perez-Aguilar, Jin Xi

  Current address: Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America

  Affiliation Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Jin Xi ,

  Contributed equally to this work with: Jose Manuel Perez-Aguilar, Jin Xi

  Affiliation Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Felipe Matsunaga,

  Affiliation Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Xu Cui,

  Affiliations Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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• Bernard Selling,

  Affiliation Impact Biologicals Inc., Swarthmore, Pennsylvania, United States of America

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• Jeffery G. Saven ,

  * E-mail: liur@uphs.upenn.edu (RL); saven@sas.upenn.edu (JGS)

  Affiliation Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Renyu Liu

  * E-mail: liur@uphs.upenn.edu (RL); saven@sas.upenn.edu (JGS)

  Affiliation Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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