Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors

• Parvin Ahooghalandari,

  Affiliation Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden

  ⨯
• Nina Hanke,

  Current address: ElexoPharm GmbH, Saarbrücken, Germany

  Affiliation Abbott Products, Hannover, Germany

  ⨯
• Michael Thorpe,

  Affiliation Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden

  ⨯
• Andreas Witte,

  Affiliation Abbott Products, Hannover, Germany

  ⨯
• Josef Messinger ,

  Contributed equally to this work with: Josef Messinger, Lars Hellman

  Current address: Orion Pharma, Espoo, Finland

  Affiliation Abbott Products, Hannover, Germany

  ⨯
• Lars Hellman

  Contributed equally to this work with: Josef Messinger, Lars Hellman

  * E-mail: Lars.Hellman@icm.uu.se (LH)

  Affiliation Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Uppsala, Sweden

  ⨯