Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

Eric K. Hoobler; Ganesha Rai; Andrew G. S. Warrilow; Steven C. Perry; Christopher J. Smyrniotis; Ajit Jadhav; Anton Simeonov; Josie E. Parker; Diane E. Kelly; David J. Maloney; S. L. Kelly; Theodore R. Holman

doi:10.1371/journal.pone.0065928

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Peer-reviewed

Research Article

Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

Eric K. Hoobler,

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Ganesha Rai,

Affiliation NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Bethesda, Maryland, United States of America
⨯
Andrew G. S. Warrilow,

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom
⨯
Steven C. Perry,

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Christopher J. Smyrniotis,

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Ajit Jadhav,

Affiliation NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Bethesda, Maryland, United States of America
⨯
Anton Simeonov,

Affiliation NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Bethesda, Maryland, United States of America
⨯
Josie E. Parker,

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom
⨯
Diane E. Kelly,

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom
⨯
David J. Maloney ,

* E-mail: maloneyd@mail.nih.gov (DJM); s.l.kelly@swansea.ac.uk (SLK); holman@ucsc.edu (TRH)

Affiliation NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Bethesda, Maryland, United States of America
⨯
S. L. Kelly ,

* E-mail: maloneyd@mail.nih.gov (DJM); s.l.kelly@swansea.ac.uk (SLK); holman@ucsc.edu (TRH)

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom
⨯
Theodore R. Holman

* E-mail: maloneyd@mail.nih.gov (DJM); s.l.kelly@swansea.ac.uk (SLK); holman@ucsc.edu (TRH)

Affiliation Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯

Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

Eric K. Hoobler,
Ganesha Rai,
Andrew G. S. Warrilow,
Steven C. Perry,
Christopher J. Smyrniotis,
Ajit Jadhav,
Anton Simeonov,
Josie E. Parker,
Diane E. Kelly,
David J. Maloney

Published: June 24, 2013
https://doi.org/10.1371/journal.pone.0065928

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