PTEN Loss Increases PD-L1 Protein Expression and Affects the Correlation between PD-L1 Expression and Clinical Parameters in Colorectal Cancer

Minmin Song; Defeng Chen; Biyan Lu; Chenliang Wang; Junxiao Zhang; Lanlan Huang; Xiaoyan Wang; Christine L. Timmons; Jun Hu; Bindong Liu; Xiaojian Wu; Lei Wang; Jianping Wang; Huanliang Liu

doi:10.1371/journal.pone.0065821

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Peer-reviewed

Research Article

PTEN Loss Increases PD-L1 Protein Expression and Affects the Correlation between PD-L1 Expression and Clinical Parameters in Colorectal Cancer

Minmin Song ,

Contributed equally to this work with: Minmin Song, Defeng Chen

Affiliations Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China
⨯
Defeng Chen ,

Contributed equally to this work with: Minmin Song, Defeng Chen

Affiliation Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Biyan Lu,

Affiliations Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China, Dongguan Health School, Dongguan, Guangdong, China
⨯
Chenliang Wang,

Affiliations Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China, Center for AIDS Health Disparities Research, Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, United States of America
⨯
Junxiao Zhang,

Affiliations Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China
⨯
Lanlan Huang,

Affiliations Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China
⨯
Xiaoyan Wang,

Affiliations Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China
⨯
Christine L. Timmons,

Affiliation Center for AIDS Health Disparities Research, Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, United States of America
⨯
Jun Hu,

Affiliation Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Bindong Liu,

Affiliation Center for AIDS Health Disparities Research, Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, United States of America
⨯
Xiaojian Wu,

Affiliation Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Lei Wang,

Affiliation Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Jianping Wang ,

* E-mail: huanliang.liu@gmail.com (HLL); wangjply@yahoo.com.cn (JPW)

Affiliation Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Huanliang Liu

* E-mail: huanliang.liu@gmail.com (HLL); wangjply@yahoo.com.cn (JPW)

Affiliations Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China
⨯

PTEN Loss Increases PD-L1 Protein Expression and Affects the Correlation between PD-L1 Expression and Clinical Parameters in Colorectal Cancer

Minmin Song,
Defeng Chen,
Biyan Lu,
Chenliang Wang,
Junxiao Zhang,
Lanlan Huang,
Xiaoyan Wang,
Christine L. Timmons,
Jun Hu,
Bindong Liu

Published: June 13, 2013
https://doi.org/10.1371/journal.pone.0065821

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