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Open Access
Peer-reviewed
Research Article
Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors
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Matthew D. Neal,
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Hongpeng Jia,
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Benjamin Eyer,
Affiliation Department of Chemistry and Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Misty Good,
Affiliation Division of Newborn Medicine, Children’s Hospital of Pittsburgh and Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Christopher J. Guerriero,
Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Chhinder P. Sodhi,
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Amin Afrazi,
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Thomas Prindle Jr,
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Congrong Ma,
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Maria Branca,
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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John Ozolek,
Affiliation Division of Pathology, Children’s Hospital of Pittsburgh and Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Jeffrey L. Brodsky,
Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Peter Wipf,
Affiliation Department of Chemistry and Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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David J. Hackam
* E-mail: david.hackam@chp.edu
Affiliation Division of Pediatric Surgery Children’s Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors
- Matthew D. Neal,
- Hongpeng Jia,
- Benjamin Eyer,
- Misty Good,
- Christopher J. Guerriero,
- Chhinder P. Sodhi,
- Amin Afrazi,
- Thomas Prindle Jr,
- Congrong Ma,
- Maria Branca
- Published: June 12, 2013
- https://doi.org/10.1371/journal.pone.0065779