Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1−/− Mice: Plausible Link between Oxidative Stress and Demyelination

Ryan T. Hamilton; Arunabh Bhattacharya; Michael E. Walsh; Yun Shi; Rochelle Wei; Yiqiang Zhang; Karl A. Rodriguez; Rochelle Buffenstein; Asish R. Chaudhuri; Holly Van Remmen

doi:10.1371/journal.pone.0065725

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Peer-reviewed

Research Article

Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1^−/− Mice: Plausible Link between Oxidative Stress and Demyelination

Ryan T. Hamilton ,

Contributed equally to this work with: Ryan T. Hamilton, Arunabh Bhattacharya

Affiliations Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
⨯
Arunabh Bhattacharya ,

Contributed equally to this work with: Ryan T. Hamilton, Arunabh Bhattacharya

Affiliations Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
⨯
Michael E. Walsh,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Yun Shi,

Affiliations Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
⨯
Rochelle Wei,

Affiliation Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
⨯
Yiqiang Zhang,

Affiliations Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
⨯
Karl A. Rodriguez,

Affiliations Department of Physiology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
⨯
Rochelle Buffenstein,

Affiliations Department of Physiology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America
⨯
Asish R. Chaudhuri ,

* E-mail: chaudhuria@uthscsa.edu (ARC); vanremmen@uthscsa.edu (HV)

Affiliations Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America, Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Holly Van Remmen

* E-mail: chaudhuria@uthscsa.edu (ARC); vanremmen@uthscsa.edu (HV)

Affiliations Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Department of Physiology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, United States of America, Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯

Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1^−/− Mice: Plausible Link between Oxidative Stress and Demyelination

Ryan T. Hamilton,
Arunabh Bhattacharya,
Michael E. Walsh,
Yun Shi,
Rochelle Wei,
Yiqiang Zhang,
Karl A. Rodriguez,
Rochelle Buffenstein,
Asish R. Chaudhuri,
Holly Van Remmen

Published: June 4, 2013
https://doi.org/10.1371/journal.pone.0065725

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