Leprdb/db Mice with Senescence Marker Protein-30 Knockout (Leprdb/dbSmp30Y/−) Exhibit Increases in Small Dense-LDL and Severe Fatty Liver Despite Being Fed a Standard Diet

Yoshitaka Kondo; Goji Hasegawa; Hiroshi Okada; Takafumi Senmaru; Michiaki Fukui; Naoto Nakamura; Morio Sawada; Jo Kitawaki; Takeshi Okanoue; Yuki Kishimoto; Akiko Amano; Naoki Maruyama; Hiroshi Obayashi; Akihito Ishigami

doi:10.1371/journal.pone.0065698

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Peer-reviewed

Research Article

Lepr^db/db Mice with Senescence Marker Protein-30 Knockout (Lepr^db/dbSmp30^Y/−) Exhibit Increases in Small Dense-LDL and Severe Fatty Liver Despite Being Fed a Standard Diet

Yoshitaka Kondo,

Affiliation Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
⨯
Goji Hasegawa,

Affiliation Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
⨯
Hiroshi Okada,

Affiliation Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
⨯
Takafumi Senmaru,

Affiliation Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
⨯
Michiaki Fukui,

Affiliation Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
⨯
Naoto Nakamura,

Affiliation Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
⨯
Morio Sawada,

Affiliation Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
⨯
Jo Kitawaki,

Affiliation Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
⨯
Takeshi Okanoue,

Affiliation Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka, Japan
⨯
Yuki Kishimoto,

Affiliation Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
⨯
Akiko Amano,

Affiliation Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
⨯
Naoki Maruyama,

Affiliation Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
⨯
Hiroshi Obayashi,

Affiliations Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan, Institute of Bio-Response Informatics, Kyoto, Japan
⨯
Akihito Ishigami

* E-mail: ishigami@tmig.or.jp

Affiliation Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
⨯

Lepr^db/db Mice with Senescence Marker Protein-30 Knockout (Lepr^db/dbSmp30^Y/−) Exhibit Increases in Small Dense-LDL and Severe Fatty Liver Despite Being Fed a Standard Diet

Yoshitaka Kondo,
Goji Hasegawa,
Hiroshi Okada,
Takafumi Senmaru,
Michiaki Fukui,
Naoto Nakamura,
Morio Sawada,
Jo Kitawaki,
Takeshi Okanoue,
Yuki Kishimoto

Published: June 3, 2013
https://doi.org/10.1371/journal.pone.0065698

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