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Open Access

Peer-reviewed

Research Article

CSTP1, a Novel Protein Phosphatase, Blocks Cell Cycle, Promotes Cell Apoptosis, and Suppresses Tumor Growth of Bladder Cancer by Directly Dephosphorylating Akt at Ser473 Site

De-Xiang Zhuo ,

Contributed equally to this work with: De-Xiang Zhuo, Xiao-Wei Zhang

Affiliations The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China, The Department of Laboratory Medicine, the First Hospital of Sanming Affiliated to Fujian Medical University, Sanming, Fujian, China
⨯
Xiao-Wei Zhang ,

Contributed equally to this work with: De-Xiang Zhuo, Xiao-Wei Zhang

Affiliation The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China
⨯
Bo Jin,

Affiliation The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China
⨯
Zheng Zhang,

Affiliation The Department of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, China
⨯
Bu-Shan Xie,

Affiliation The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China
⨯
Cheng-Lin Wu,

Affiliation The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China
⨯
Kan Gong ,

* E-mail: zbmao@bjmu.edu.cn (ZBM); gongkan2004@yahoo.com.cn (KG)

Affiliation The Department of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, China
⨯
Ze-Bin Mao

* E-mail: zbmao@bjmu.edu.cn (ZBM); gongkan2004@yahoo.com.cn (KG)

Affiliation The Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing, China
⨯

CSTP1, a Novel Protein Phosphatase, Blocks Cell Cycle, Promotes Cell Apoptosis, and Suppresses Tumor Growth of Bladder Cancer by Directly Dephosphorylating Akt at Ser473 Site

De-Xiang Zhuo,
Xiao-Wei Zhang,
Bo Jin,
Zheng Zhang,
Bu-Shan Xie,
Cheng-Lin Wu,
Kan Gong,
Ze-Bin Mao

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Published: June 17, 2013
https://doi.org/10.1371/journal.pone.0065679

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Bladder cancer
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Phosphatases
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Cell cycle and cell division
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Apoptosis
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Transfection
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Small interfering RNA
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Hyperexpression techniques
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Plasmid construction
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