Immunization of Aged Pigs with Attenuated Pseudorabies Virus Vaccine Combined with CpG Oligodeoxynucleotide Restores Defective Th1 Immune Responses

Feiping Ming; Jun Yang; Pinpin Chu; Miaopeng Ma; Juqing Shi; Haiming Cai; Chaoyuan Huang; Huazhou Li; Zhenggu Jiang; Houguang Wang; Weifang Wang; Shuiqing Zhang; Linghua Zhang

doi:10.1371/journal.pone.0065536

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Open Access

Peer-reviewed

Research Article

Immunization of Aged Pigs with Attenuated Pseudorabies Virus Vaccine Combined with CpG Oligodeoxynucleotide Restores Defective Th1 Immune Responses

Feiping Ming ,

Contributed equally to this work with: Feiping Ming, Jun Yang

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Jun Yang ,

Contributed equally to this work with: Feiping Ming, Jun Yang

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Pinpin Chu,

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Miaopeng Ma,

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Juqing Shi,

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Haiming Cai,

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Chaoyuan Huang,

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Huazhou Li,

Affiliation Swine Seed Breeding Center of Guangzhou, Guangzhou, China
⨯
Zhenggu Jiang,

Affiliation Swine Seed Breeding Center of Guangzhou, Guangzhou, China
⨯
Houguang Wang,

Affiliation Swine Seed Breeding Center of Guangzhou, Guangzhou, China
⨯
Weifang Wang,

Affiliation Swine Seed Breeding Center of Guangzhou, Guangzhou, China
⨯
Shuiqing Zhang,

Affiliation College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China
⨯
Linghua Zhang

* E-mail: lhzhang73212000@yahoo.com.cn

Affiliations College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, China, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Agricultural University, Guangzhou, Guangdong, China
⨯

Immunization of Aged Pigs with Attenuated Pseudorabies Virus Vaccine Combined with CpG Oligodeoxynucleotide Restores Defective Th1 Immune Responses

Feiping Ming,
Jun Yang,
Pinpin Chu,
Miaopeng Ma,
Juqing Shi,
Haiming Cai,
Chaoyuan Huang,
Huazhou Li,
Zhenggu Jiang,
Houguang Wang

Published: June 13, 2013
https://doi.org/10.1371/journal.pone.0065536

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