Systemic Administration of Abeta mAb Reduces Retinal Deposition of Abeta and Activated Complement C3 in Age-Related Macular Degeneration Mouse Model

Ian Catchpole; Volker Germaschewski; Jaimie Hoh Kam; Peter Lundh von Leithner; Susannah Ford; Gerald Gough; Peter Adamson; Philip Overend; Jan Hilpert; Francisco J. López; Yin Shan Eric Ng; Pete Coffey; Glen Jeffery

doi:10.1371/journal.pone.0065518

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Peer-reviewed

Research Article

Systemic Administration of Abeta mAb Reduces Retinal Deposition of Abeta and Activated Complement C3 in Age-Related Macular Degeneration Mouse Model

Ian Catchpole ,

Contributed equally to this work with: Ian Catchpole, Volker Germaschewski, Jaimie Hoh Kam

* E-mail: ian.r.catchpole@gsk.com

Affiliations Topical BioPharm Discovery Research and Development Unit, King of Prussia, Philadelphia, Pennsylvania, United States of America, GSK Ophthalmology, King of Prussia, Philadelphia, Pennsylvania, United States of America
⨯
Volker Germaschewski ,

Contributed equally to this work with: Ian Catchpole, Volker Germaschewski, Jaimie Hoh Kam

Current address: Kymab Limited, Cambridge, United Kingdom

Affiliation Topical BioPharm Discovery Research and Development Unit, King of Prussia, Philadelphia, Pennsylvania, United States of America
⨯
Jaimie Hoh Kam ,

Contributed equally to this work with: Ian Catchpole, Volker Germaschewski, Jaimie Hoh Kam

Affiliation Institute of Ophthalmology, University College London, London, United Kingdom
⨯
Peter Lundh von Leithner,

Affiliation Institute of Ophthalmology, University College London, London, United Kingdom
⨯
Susannah Ford,

Affiliation Topical BioPharm Discovery Research and Development Unit, King of Prussia, Philadelphia, Pennsylvania, United States of America
⨯
Gerald Gough,

Affiliation Topical BioPharm Discovery Research and Development Unit, King of Prussia, Philadelphia, Pennsylvania, United States of America
⨯
Peter Adamson,

Affiliation GSK Ophthalmology, King of Prussia, Philadelphia, Pennsylvania, United States of America
⨯
Philip Overend,

Affiliation BioPharm Discovery Medicine, GlaxoSmithKline, Stevenage, Herts, United Kingdom
⨯
Jan Hilpert,

Current address: GSK Neurosciences, GlaxoSmithKline, Shanghai, China

Affiliation BioPharm Discovery Medicine, GlaxoSmithKline, Stevenage, Herts, United Kingdom
⨯
Francisco J. López,

Affiliation GSK Ophthalmology, King of Prussia, Philadelphia, Pennsylvania, United States of America
⨯
Yin Shan Eric Ng,

Affiliation Institute of Ophthalmology, University College London, London, United Kingdom
⨯
Pete Coffey,

Affiliation Institute of Ophthalmology, University College London, London, United Kingdom
⨯
Glen Jeffery

Affiliation Institute of Ophthalmology, University College London, London, United Kingdom
⨯

Systemic Administration of Abeta mAb Reduces Retinal Deposition of Abeta and Activated Complement C3 in Age-Related Macular Degeneration Mouse Model

Ian Catchpole,
Volker Germaschewski,
Jaimie Hoh Kam,
Peter Lundh von Leithner,
Susannah Ford,
Gerald Gough,
Peter Adamson,
Philip Overend,
Jan Hilpert,
Francisco J. López

Published: June 14, 2013
https://doi.org/10.1371/journal.pone.0065518

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