Redox Factor-1 Activates Endothelial SIRTUIN1 through Reduction of Conserved Cysteine Sulfhydryls in Its Deacetylase Domain

Saet-Byel Jung; Cuk-Seong Kim; Young-Rae Kim; Asma Naqvi; Tohru Yamamori; Santosh Kumar; Ajay Kumar; Kaikobad Irani

doi:10.1371/journal.pone.0065415

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Peer-reviewed

Research Article

Redox Factor-1 Activates Endothelial SIRTUIN1 through Reduction of Conserved Cysteine Sulfhydryls in Its Deacetylase Domain

Saet-Byel Jung ,

Contributed equally to this work with: Saet-Byel Jung, Cuk-Seong Kim, Young-Rae Kim

Current address: Division of Endocrinology, Department of Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Cuk-Seong Kim ,

Contributed equally to this work with: Saet-Byel Jung, Cuk-Seong Kim, Young-Rae Kim

Current address: Department of Physiology, Chungnam National University School of Medicine, Daejeon, Republic of Korea

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Young-Rae Kim ,

Contributed equally to this work with: Saet-Byel Jung, Cuk-Seong Kim, Young-Rae Kim

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Asma Naqvi,

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Tohru Yamamori,

Current address: School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Santosh Kumar,

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Ajay Kumar,

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Kaikobad Irani

* E-mail: iranik@upmc.edu

Current address: Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa, United States of America

Affiliation Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Redox Factor-1 Activates Endothelial SIRTUIN1 through Reduction of Conserved Cysteine Sulfhydryls in Its Deacetylase Domain

Saet-Byel Jung,
Cuk-Seong Kim,
Young-Rae Kim,
Asma Naqvi,
Tohru Yamamori,
Santosh Kumar,
Ajay Kumar,
Kaikobad Irani

Published: June 3, 2013
https://doi.org/10.1371/journal.pone.0065415

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Thiols
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Cysteine
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Immunoprecipitation
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