A Loss-of-Function Screen for Phosphatases that Regulate Neurite Outgrowth Identifies PTPN12 as a Negative Regulator of TrkB Tyrosine Phosphorylation

Malene Ambjørn; Véronique Dubreuil; Federico Miozzo; Fabienne Nigon; Bente Møller; Shohreh Issazadeh-Navikas; Jacob Berg; Michael Lees; Jan Sap

doi:10.1371/journal.pone.0065371

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Peer-reviewed

Research Article

A Loss-of-Function Screen for Phosphatases that Regulate Neurite Outgrowth Identifies PTPN12 as a Negative Regulator of TrkB Tyrosine Phosphorylation

Malene Ambjørn,

Affiliation Department of Biomedical Sciences and Biotechnology Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Véronique Dubreuil,

Affiliation Epigenetics and Cell Fate, University of Paris, Sorbonne Paris Cité, Paris, France
⨯
Federico Miozzo,

Affiliation Epigenetics and Cell Fate, University of Paris, Sorbonne Paris Cité, Paris, France
⨯
Fabienne Nigon,

Affiliation Epigenetics and Cell Fate, University of Paris, Sorbonne Paris Cité, Paris, France
⨯
Bente Møller,

Affiliation Department of Biomedical Sciences and Biotechnology Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Shohreh Issazadeh-Navikas,

Affiliation Department of Biomedical Sciences and Biotechnology Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Jacob Berg,

Affiliation Department of Wind Energy, Technical University of Denmark, Roskilde, Denmark
⨯
Michael Lees,

Affiliation Department of Biomedical Sciences and Biotechnology Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Jan Sap

* E-mail: jan.sap@univ-paris-diderot.fr

Affiliations Department of Biomedical Sciences and Biotechnology Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Epigenetics and Cell Fate, University of Paris, Sorbonne Paris Cité, Paris, France
⨯

A Loss-of-Function Screen for Phosphatases that Regulate Neurite Outgrowth Identifies PTPN12 as a Negative Regulator of TrkB Tyrosine Phosphorylation

Malene Ambjørn,
Véronique Dubreuil,
Federico Miozzo,
Fabienne Nigon,
Bente Møller,
Shohreh Issazadeh-Navikas,
Jacob Berg,
Michael Lees,
Jan Sap

Published: June 13, 2013
https://doi.org/10.1371/journal.pone.0065371

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Neurites
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Small interfering RNA
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Phosphatases
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Transfection
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Regulator genes
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Neurons
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Phosphorylation
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