Hypoxia–Induced Cytotoxic Drug Resistance in Osteosarcoma Is Independent of HIF-1Alpha

Open Access

Peer-reviewed

Research Article

Jennifer Adamski,

Affiliations Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, Manchester, United Kingdom, Institute of Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, Department of Paediatric Oncology, Royal Manchester Children’s Hospital, Manchester, United Kingdom
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Andrew Price,

Affiliation Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, Manchester, United Kingdom
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Caroline Dive,

Affiliations Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, Manchester, United Kingdom, Institute of Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
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Guy Makin

* E-mail: Guy.makin@manchester.ac.uk

Affiliations Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, Manchester, United Kingdom, Institute of Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, Department of Paediatric Oncology, Royal Manchester Children’s Hospital, Manchester, United Kingdom
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Hypoxia
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Apoptosis
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Osteosarcoma cells
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Transfection
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Drug dependence
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Sex ratio
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Small interfering RNA
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Osteosarcoma
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